ParkinsonCanadaV1, Main, Exploration, bibRecord, 001507

Occupational Exposure to Whole-Body Vibration and Parkinson's Disease: Results From a Population-based Case-Control Study

Identifieur interne : 001507 ( Main/Exploration ); précédent : 001506; suivant : 001508

Occupational Exposure to Whole-Body Vibration and Parkinson's Disease: Results From a Population-based Case-Control Study

Auteurs : M. Anne Harris [Canada] ; Stephen A. Marion [Canada] ; John J. Spinelli [Canada] ; Joseph K. C. Tsui [Canada] ; Kay Teschke [Canada]

Source :

American journal of epidemiology [ 0002-9262 ] ; 2012.

RBID : Pascal:12-0351327

Descripteurs français

Pascal (Inist)
- Maladie de Parkinson, Exposition professionnelle, Médecine du travail, Corps entier, Vibration, Résultat, Santé publique, Population, Etude cas témoin, Epidémiologie.
Wicri :
- topic : Médecine du travail, Santé publique.

English descriptors

KwdEn :
- Case control study, Epidemiology, Occupational exposure, Occupational medicine, Parkinson disease, Population, Public health, Result, Vibration, Whole body.

Abstract

Mechanical stress producing head injury is associated with Parkinson's disease, suggesting that relations with other physical hazards such as whole-body vibration (WBV) should be tested. In this study, the authors evaluated the relation between occupational exposure to WBV and Parkinson's disease. A population-based case-control study with 403 cases and 405 controls was conducted in British Columbia, Canada, between 2001 and 2008. From detailed occupational histories and published measurements, metrics of occupational WBV exposure were constructed and tested for associations with Parkinson's disease using logistic regression and adjusting for age and sex first, and then also for smoking and history of head injury. While ever being occupationally exposed to WBV was inversely associated with Parkinson's disease (odds ratio = 0.67, 95% confidence interval: 0.48, 0.94), higher intensities had consistently elevated odds ratios, with a statistically significant effect being noted for intermediate intensities when exposures were restricted to the 10 years or more prior to diagnosis. Possible mechanisms of an inverse relation between low levels of WBV exposure and Parkinson's disease could include direct protective effects or correlation with other protective effects such as exercise. Higher intensities of WBV could result in micro-injury, leading to vascular or inflammatory pathology in susceptible neurons.

Affiliations:

Canada

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to stream PascalFrancis, to step Curation: 000A79
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to stream Main, to step Merge: 001552
to stream Main, to step Curation: 001507

Le document en format XML

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<front><div type="abstract" xml:lang="en">Mechanical stress producing head injury is associated with Parkinson's disease, suggesting that relations with other physical hazards such as whole-body vibration (WBV) should be tested. In this study, the authors evaluated the relation between occupational exposure to WBV and Parkinson's disease. A population-based case-control study with 403 cases and 405 controls was conducted in British Columbia, Canada, between 2001 and 2008. From detailed occupational histories and published measurements, metrics of occupational WBV exposure were constructed and tested for associations with Parkinson's disease using logistic regression and adjusting for age and sex first, and then also for smoking and history of head injury. While ever being occupationally exposed to WBV was inversely associated with Parkinson's disease (odds ratio = 0.67, 95% confidence interval: 0.48, 0.94), higher intensities had consistently elevated odds ratios, with a statistically significant effect being noted for intermediate intensities when exposures were restricted to the 10 years or more prior to diagnosis. Possible mechanisms of an inverse relation between low levels of WBV exposure and Parkinson's disease could include direct protective effects or correlation with other protective effects such as exercise. Higher intensities of WBV could result in micro-injury, leading to vascular or inflammatory pathology in susceptible neurons.</div>
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	La maladie de Parkinson au Canada (serveur d'exploration)
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La maladie de Parkinson au Canada (serveur d'exploration)

Occupational Exposure to Whole-Body Vibration and Parkinson's Disease: Results From a Population-based Case-Control Study

Occupational Exposure to Whole-Body Vibration and Parkinson's Disease: Results From a Population-based Case-Control Study

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri